Dysbiosis: a void where C. diff thrives
Dysbiosis is the disruption of the volume and diversity of the gut microbiome. The causes can be attributed to stress, diet, hygiene, and use of antibiotics. Dysbiosis has been associated with a range of different gastrointestinal (GI) and non-GI diseases including neurologic, metabolic, liver, inflammatory, and infectious diseases.1-3
The gut microbiota generally play a role in colonization resistance by which the native organisms prevent pathogenic microbes from flourishing. Disruption of the gut microbiome leads to an environment suited for the proliferation of Clostridioides difficile.1,4
When the relationship between the gut and its healthy flora becomes imbalanced, dysbiosis results…leading to an intestinal microenvironment susceptible to pathogenic insult from opportunistic bacteria, such as C. diff—capable of causing a wide spectrum of symptoms ranging from mild diarrhea to sepsis.1
To rectify dysbiosis, restoration of the gut microbiome is essential.1-3
While this may occur as a natural process, therapeutic intervention may also be required.
C. diff infection can be more
dangerous when it recurs.
Can the power of the microbiome help
change the course of treatment?
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- Bien J, Palagani V, Bozko P. The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease? Therap Adv Gastroenterol. 2013;6(1):53-68.
- Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis. Cell Mol Life Sci. 2017;74(16):2959-2977.
- Riaz Rajoka MS, Shi J, Mehwish HM, et al. Interaction between diet composition and gut microbiota and its impact on gastrointestinal tract health. Food Science and Human Wellness. 2017;6(3):121-130.
- Staley C, Khoruts A, Sadowsky MJ. Contemporary applications of fecal microbiota transplantation to treat intestinal diseases in humans. Arch Med Res. 2017;48(8):766-773.